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Article

Mediator independently orchestrates multiple steps of preinitiation complex assembly in vivo.

Nucleic acids research - 30 Oct 2015

Eyboulet Fanny, Wydau-Dematteis Sandra, Eychenne Thomas, Alibert Olivier, Neil Helen, Boschiero Claire, Nevers Marie-Claire, Volland Hervé, Cornu David, Redeker Virginie, Werner Michel, Soutourina Julie

Abstract excerpt

Mediator is a large multiprotein complex conserved in all eukaryotes, which has a crucial coregulator function in transcription by RNA polymerase II (Pol II). However, the molecular mechanisms of its action in vivo remain to be understood. Med17 is an essential and central component of the Mediator head module. In this work, we utilised our large collection of conditional temperature-sensitive med17 mutants to...

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Identifiers

PMID: 26240385
DOI: 10.1093/nar/gkv782
PMCID: PMC4627066

Genes

TBP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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