Article
Two conserved modules of Schizosaccharomyces pombe Mediator regulate distinct cellular pathways.
Nucleic acids research - 1 May 2008
Linder Tomas, Rasmussen Nina N, Samuelsen Camilla O, Chatzidaki Emmanouella, Baraznenok Vera, Beve Jenny, Henriksen Peter, Gustafsson Claes M, Holmberg Steen
Abstract excerpt
Mediator is an evolutionary conserved coregulator complex required for transcription of almost all RNA polymerase II-dependent genes. The Schizosaccharomyces pombe Mediator consists of two dissociable components-a core complex organized into a head and middle domain as well as the Cdk8 regulatory subcomplex. In this work we describe a functional characterization of the S. pombe Mediator. We report the...
Topics
- Alleles
- Cell Wall
- Cyclin-Dependent Kinase 8
- Cyclin-Dependent Kinases
- Gene Expression Profiling
- Mutation
- Phenotype
- Protein Subunits
- Saccharomyces cerevisiae
- Schizosaccharomyces
- Schizosaccharomyces pombe Proteins
- Trans-Activators