Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional interplay between Mediator and TFIIB in preinitiation complex assembly in relation to promoter architecture.

Genes & development - 15 Sept 2016

Eychenne Thomas, Novikova Elizaveta, Barrault Marie-Bénédicte, Alibert Olivier, Boschiero Claire, Peixeiro Nuno, Cornu David, Redeker Virginie, Kuras Laurent, Nicolas Pierre, Werner Michel, Soutourina Julie

Abstract excerpt

Mediator is a large coregulator complex conserved from yeast to humans and involved in many human diseases, including cancers. Together with general transcription factors, it stimulates preinitiation complex (PIC) formation and activates RNA polymerase II (Pol II) transcription. In this study, we analyzed how Mediator acts in PIC assembly using in vivo, in vitro, and in silico approaches. We revealed an essential...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatin
Share to Mediator Complex

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Promoter Regions, Genetic

Share to Protein Binding

Share to Protein Multimerization

Share to Saccharomyces cerevisiae

Share to Saccharomyces cerevisiae Proteins

Share to Transcription Factor TFIIB

Source

Open in PubMed Open full text

Identifiers

PMID: 27688401
DOI: 10.1101/gad.285775.116
PMCID: PMC5066617

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional interplay between Mediator and TFIIB in preinitiation complex assembly in relation to promoter architecture.PMID 27688401Read ↗

Mediator-dependent recruitment of TFIIH modules in preinitiation complex.Semantic proximity Read ↗

The Mediator Complex: Progress over the Past DecadeSemantic proximity Read ↗

Mediator independently orchestrates multiple steps of preinitiation complex assembly in vivo.Semantic proximity Read ↗

Direct interaction of RNA polymerase II and mediator required for transcription in vivo.Semantic proximity Read ↗

Mediator-RNA Polymerase II Interactions Critical for Transcriptional Activation Are Mediated by the N-terminal Half of MED14 and C-terminal Domain of RPB1Semantic proximity Read ↗

Mediator head subcomplex Med11/22 contains a common helix bundle building block with a specific function in transcription initiation complex stabilization.Semantic proximity Read ↗

Functional interplay between Mediator and RSC chromatin remodeling complex controls nucleosome-depleted region maintenance at promotersSemantic proximity Read ↗

Structure of human Mediator-RNA polymerase II transcription pre-initiation complexSemantic proximity Read ↗

Genome-wide association of mediator and RNA polymerase II in wild-type and mediator mutant yeast.Semantic proximity Read ↗

Core Mediator structure at 3.4 Å extends model of transcription initiation complex.Semantic proximity Read ↗

Mediator is an intrinsic component of the basal RNA polymerase II machinery in vivo.Semantic proximity Read ↗

Genome-wide occupancy profile of mediator and the Srb8-11 module reveals interactions with coding regions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.