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Article

Genome-wide occupancy profile of mediator and the Srb8-11 module reveals interactions with coding regions.

Molecular cell - 21 Apr 2006

Zhu Xuefeng, Wirén Marianna, Sinha Indranil, Rasmussen Nina N, Linder Tomas, Holmberg Steen, Ekwall Karl, Gustafsson Claes M

Abstract excerpt

Mediator exists in a free form containing the Med12, Med13, CDK8, and CycC subunits (the Srb8-11 module) and a smaller form, which lacks these four subunits and associates with RNA polymerase II (Pol II), forming a holoenzyme. We use chromatin immunoprecipitation (ChIP) and DNA microarrays to investigate genome-wide localization of Mediator and the Srb8-11 module in fission yeast. Mediator and the Srb8-11 module...

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Identifiers

PMID: 16630887
DOI: 10.1016/j.molcel.2006.03.032

Genes

CDK8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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