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Article

Direct interaction of RNA polymerase II and mediator required for transcription in vivo.

Science (New York, N.Y.) - 18 Mar 2011

Soutourina Julie, Wydau Sandra, Ambroise Yves, Boschiero Claire, Werner Michel

Abstract excerpt

Gene transcription is highly regulated. Altered transcription can lead to cancer or developmental diseases. Mediator, a multisubunit complex conserved among eukaryotes, is generally required for RNA polymerase II (Pol II) transcription. An interaction between the two complexes is known, but its molecular nature and physiological role are unclear. We identify a direct physical interaction between the Rpb3 Pol II...

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PMID: 21415355
DOI: 10.1126/science.1200188

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Direct interaction of RNA polymerase II and mediator required for transcription in vivo.PMID 21415355Read ↗

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