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Article

Mediator-dependent recruitment of TFIIH modules in preinitiation complex.

Molecular cell - 8 Aug 2008

Esnault Cyril, Ghavi-Helm Yad, Brun Sylvain, Soutourina Julie, Van Berkum Nynke, Boschiero Claire, Holstege Frank, Werner Michel

Abstract excerpt

In vitro, without Mediator, the association of general transcription factors (GTF) and RNA polymerase II (Pol II) in preinitiation complexes (PIC) occurs in an orderly fashion. In this work, we explore the in vivo function of Mediator in GTF recruitment to PIC. A direct interaction between Med11 Mediator head subunit and Rad3 TFIIH subunit was identified. We explored the significance of this interaction and those...

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Identifiers

PMID: 18691966
DOI: 10.1016/j.molcel.2008.06.021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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