Article

Mediator-RNA Polymerase II Interactions Critical for Transcriptional Activation Are Mediated by the N-terminal Half of MED14 and C-terminal Domain of RPB1

2022-04-27

Abstract excerpt

<h4>ABSTRACT</h4> Mediator is a large and evolutionarily conserved coactivator complex essential for RNA polymerase II (Pol II)-mediated gene regulation at multiple steps of the transcription process, including preinitiation complex (PIC) assembly and function. Here, we used the MultiBac baculovirus expression system to generate recombinant human core Mediator subcomplexes and subsequent biochemical approaches to...

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Literature Corpus work: 50c55a32-34ae-5765-a185-3e425fb438af
DOI: 10.1101/2022.04.27.489650

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Mediator-RNA Polymerase II Interactions Critical for Transcriptional Activation Are Mediated by the N-terminal Half of MED14 and C-terminal Domain of RPB1DOI 10.1101/2022.04.27.489650Read

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