Nonlinear cerebral atrophy patterns across the Alzheimer's disease continuum: impact of APOE4 genotype.

doi:10.1016/j.neurobiolaging.2015.06.027

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Article

Nonlinear cerebral atrophy patterns across the Alzheimer's disease continuum: impact of APOE4 genotype.

Neurobiology of aging - 1 Oct 2015

Gispert J D, Rami L, Sánchez-Benavides G, Falcon C, Tucholka A, Rojas S, Molinuevo J L

Abstract excerpt

The progression of Alzheimer's disease (AD) is characterized by complex trajectories of cerebral atrophy that are affected by interactions with age and apolipoprotein E allele ε4 (APOE4) status. In this article, we report the nonlinear volumetric changes in gray matter across the full biological spectrum of the disease, represented by the AD-cerebrospinal fluid (CSF) index. This index reflects the subject's level...

Topics

Aged
Alleles
Alzheimer Disease
Apolipoproteins E
Atrophy
Disease Progression
Female
Genotype
Gray Matter
Heterozygote
Hippocampus
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Magnetic Resonance Imaging

Male

Middle Aged

Neuroimaging

Parietal Lobe

Temporal Lobe

Source

Open in PubMed

Identifiers

PMID: 26239178
DOI: 10.1016/j.neurobiolaging.2015.06.027

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