Multimodal and longitudinal characterization of distinct tau and atrophy clusters in Alzheimer’s disease spectrum

Abstract excerpt

Neuropathological and neuroimaging studies have identified several (endo-)phenotypes of Alzheimer's disease (AD), suggesting a substantial heterogeneity in cerebral atrophy and tau spreading patterns. We included in our study a total of 320 participants, including healthy controls (N = 154) and patients across the AD spectrum (N = 166). We identified clusters of cerebral atrophy and tau PET uptake using a...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Alzheimer's disease research and treatments
• Share to Dementia and Cognitive Impairment Research
• Share to Neurological Disease Mechanisms and Treatments