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Article

Voxel-wise insights into early Alzheimer's disease pathology progression: the association with APOE and memory decline.

GeroScience - 1 Aug 2025

Wybitul Maha, Langer Nicolas, Hock Christoph, Gietl Anton, Treyer Valerie

Abstract excerpt

Longitudinal investigation of the Apolipoprotein E (APOE) genotype's impact on Alzheimer's disease (AD) biomarker progression, focusing on amyloid beta (Aβ) accumulation and gray matter (GM) atrophy, integrating cognitive decline and baseline levels. Longitudinal florbetapir-PET and T1-weighted MRI data from 100 cognitively normal (CN) and mild cognitive impaired (MCI) participants both with considerable global...

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Source

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Identifiers

PMID: 40167963
DOI: 10.1007/s11357-025-01610-z
PMCID: PMC12397024

Genes

APOE

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