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Article

T cell receptor dwell times control the kinase activity of Zap70.

Nature immunology - 1 Sept 2015

Klammt Christian, Novotná Lucie, Li Dongyang T, Wolf Miriam, Blount Amy, Zhang Kai, Fitchett Jonathan R, Lillemeier Björn F

Abstract excerpt

Kinase recruitment to membrane receptors is essential for signal transduction. However, the underlying regulatory mechanisms are poorly understood. We investigated how conformational changes control T cell receptor (TCR) association and activity of the kinase Zap70. Structural analysis showed that TCR binding or phosphorylation of Zap70 triggers a transition from a closed, autoinhibited conformation to an open...

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Identifiers

PMID: 26237552
DOI: 10.1038/ni.3231
PMCID: PMC4605427

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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