T cell receptor-dependent S-acylation of ZAP-70 controls activation of T cells.

doi:10.1016/j.jbc.2021.100311

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Article

T cell receptor-dependent S-acylation of ZAP-70 controls activation of T cells.

The Journal of biological chemistry - 1 Jan 2000

Tewari Ritika, Shayahati Bieerkehazhi, Fan Ying, Akimzhanov Askar M

Abstract excerpt

ZAP-70 is a tyrosine kinase essential for T cell immune responses. Upon engagement of the T cell receptor (TCR), ZAP-70 is recruited to the specialized plasma membrane domains, becomes activated, and is released to phosphorylate its laterally segregated targets. A shift in ZAP-70 distribution at the plasma membrane is recognized as a critical step in TCR signal transduction and amplification. However, the...

Topics

Acylation
Acyltransferases
Cell Membrane
Gene Expression Regulation, Enzymologic
Humans
Immunity, Cellular
Lipoylation
Mutation
Protein Processing, Post-Translational
Receptors, Antigen, T-Cell
Signal Transduction
Substrate Specificity
T-Lymphocytes
ZAP-70 Protein-Tyrosine Kinase

Source

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Identifiers

PMID: 33482200
DOI: 10.1016/j.jbc.2021.100311
PMCID: PMC7949058

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