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Article

Stability of an autoinhibitory interface in the structure of the tyrosine kinase ZAP-70 impacts T cell receptor response.

Proceedings of the National Academy of Sciences of the United States of America - 8 Dec 2009

Deindl Sebastian, Kadlecek Theresa A, Cao Xiaoxian, Kuriyan John, Weiss Arthur

Abstract excerpt

The delivery of signals from the activated T cell antigen receptor (TCR) inside the cell relies on the protein tyrosine kinase ZAP-70 (zeta-associated protein of 70 kDa). A recent crystal structure of inactive full-length ZAP-70 suggests that a central interface formed by the docking of the two SH2 domains of ZAP-70 onto the kinase domain is crucial for suppressing catalytic activity. Here we validate the...

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Identifiers

PMID: 19920178
DOI: 10.1073/pnas.0911512106
PMCID: PMC2778570

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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