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Article

Impaired Reelin-Dab1 Signaling Contributes to Neuronal Migration Deficits of Tuberous Sclerosis Complex.

Cell reports - 11 Aug 2015

Moon Uk Yeol, Park Jun Young, Park Raehee, Cho Jennifer Y, Hughes Lucinda J, McKenna James, Goetzl Laura, Cho Seo-Hee, Crino Peter B, Gambello Michael J, Kim Seonhee

Abstract excerpt

Tuberous sclerosis complex (TSC) is associated with neurodevelopmental abnormalities, including defects in neuronal migration. However, the alterations in cell signaling mechanisms critical for migration and final positioning of neurons in TSC remain unclear. Our detailed cellular analyses reveal that reduced Tsc2 in newborn neurons causes abnormalities in leading processes of migrating neurons, accompanied by...

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Share to Cell Adhesion Molecules, Neuronal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26235615
DOI: 10.1016/j.celrep.2015.07.013
PMCID: PMC4536164

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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