Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activation of Aurora-A is essential for neuronal migration via modulation of microtubule organization.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 8 Aug 2012

Takitoh Takako, Kumamoto Kanako, Wang Chen-Chi, Sato Makoto, Toba Shiori, Wynshaw-Boris Anthony, Hirotsune Shinji

Abstract excerpt

Neuronal migration is a critical feature to ensure proper location and wiring of neurons during cortical development. Postmitotic neurons migrate from the ventricular zone into the cortical plate to establish neuronal lamina in an "inside-out" gradient of maturation. Here, we report that the mitotic kinase Aurora-A is critical for the regulation of microtubule organization during neuronal migration via an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aurora Kinase A
Share to Aurora Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bromodeoxyuridine

Share to Cerebellum

Share to Cyclin-Dependent Kinase 5

Share to Microtubules

Share to Piperazines

Share to Purines

Source

Open in PubMed Open full text

Identifiers

PMID: 22875938
DOI: 10.1523/JNEUROSCI.5664-11.2012
PMCID: PMC6621011

Genes

CDK5
NDEL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activation of Aurora-A is essential for neuronal migration via modulation of microtubule organization.PMID 22875938Read ↗

An essential role of the aPKC-Aurora A-NDEL1 pathway in neurite elongation by modulation of microtubule dynamics.Semantic proximity Read ↗

Neuronal migration: unraveling the molecular pathway with humans, mice, and a fungus.Semantic proximity Read ↗

Aurora-A kinase is essential for bipolar spindle formation and early development.Semantic proximity Read ↗

Impaired Reelin-Dab1 Signaling Contributes to Neuronal Migration Deficits of Tuberous Sclerosis Complex.Semantic proximity Read ↗

Molecular genetics of neuronal migration disorders.Semantic proximity Read ↗

Extra‐cell cycle regulatory functions of cyclin‐dependent kinases (<scp>CDK</scp>) and <scp>CDK</scp> inhibitor proteins contribute to brain development and neurological disordersSemantic proximity Read ↗

Filamin A Regulates Neural Progenitor Proliferation and Cortical Size through Wee1-Dependent Cdk1 PhosphorylationSemantic proximity Read ↗

Aurora kinase A controls meiosis I progression in mouse oocytesSemantic proximity Read ↗

CDKL5’s role in microtubule-based transport and cognitive functionSemantic proximity Read ↗

Katanin p80, NuMA and cytoplasmic dynein cooperate to control microtubule dynamics.Semantic proximity Read ↗

Dynamic association of a tumor amplified kinase, Aurora-A, with the centrosome and mitotic spindle.Semantic proximity Read ↗

The Role of Nde1 phosphorylation in interkinetic nuclear migration and neural migration during cortical development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.