Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Timing of mTOR activation affects tuberous sclerosis complex neuropathology in mouse models

1 Jan 2013

Abstract excerpt

Tuberous sclerosis complex (TSC) is a dominantly inherited disease with high penetrance and morbidity, and is caused by mutations in either of two genes, TSC1 or TSC2. Most affected individuals display severe neurological manifestations - such as intractable epilepsy, mental retardation and autism - that are intimately associated with peculiar CNS lesions known as cortical tubers (CTs). The existence of a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Tuberous Sclerosis Complex Research

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 23744272
DOI: 10.1242/dmm.012096

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Timing of mTOR activation affects tuberous sclerosis complex neuropathology in mouse modelsPMID 23744272Read ↗

Complex Neurological Phenotype in Mutant Mice Lacking Tsc2 in Excitatory Neurons of the Developing Forebrain(123).Semantic proximity Read ↗

Sustained activation of mTOR pathway in embryonic neural stem cells leads to development of tuberous sclerosis complex-associated lesions.Semantic proximity Read ↗

A Mouse Model of Tuberous Sclerosis: Neuronal Loss of Tsc1 Causes Dysplastic and Ectopic Neurons, Reduced Myelination, Seizure Activity, and Limited SurvivalSemantic proximity Read ↗

Loss of Tsc2 in Neonatal V-SVZ Neural Stem Cells Causes Rare Malformations Tsc2 Mutation Causes Rare MalformationsSemantic proximity Read ↗

TSC1/TSC2 signaling in the CNSSemantic proximity Read ↗

Mechanisms of neurocognitive dysfunction and therapeutic considerations in tuberous sclerosis complexSemantic proximity Read ↗

Comparative analysis of Tsc1 and Tsc2 single and double radial glial cell mutants.Semantic proximity Read ↗

TSC-mTORC1 Pathway in Postnatal V-SVZ NeurodevelopmentSemantic proximity Read ↗

Expression profiling in tuberous sclerosis complex (TSC) knockout mouse astrocytes to characterize human TSC brain pathologySemantic proximity Read ↗

Mechanistic target of rapamycin signaling in human nervous system development and diseaseSemantic proximity Read ↗

mTOR Signaling and Neural Stem Cells: The Tuberous Sclerosis Complex ModelSemantic proximity Read ↗

Hypomyelination following deletion of Tsc2 in oligodendrocyte precursorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.