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Article

Alternative Splicing of Disabled-1 Controls Multipolar-to-Bipolar Transition of Migrating Neurons in the Neocortex.

Cerebral cortex (New York, N.Y. : 1991) - 1 Oct 2018

Zhang Bin, Wang Weiwei, Zhang Zhenjie, Hu Yaling, Meng Fan, Wang Fan, Lou Huifang, Zhu Liya, Godbout Roseline, Duan Shumin, Gao Zhihua

Abstract excerpt

Multipolar-to-bipolar transition (MBT) is crucial for the neuronal migration and positioning in the neocortex. Reelin-Disabled-1 (Dab1) signaling plays a pivotal role in neuronal migration, yet how Dab1 coordinatively regulates downstream molecules to affect MBT remains unclear. We have previously found that alternative splicing produces multiple Dab1 isoforms with different tyrosine motifs and differential...

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PMID: 28968791
DOI: 10.1093/cercor/bhx212

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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