Article
Reelin sets the pace of neocortical neurogenesis.
Development (Cambridge, England) - 1 Dec 2011
Lakomá Jarmila, Garcia-Alonso Luis, Luque Juan M
Abstract excerpt
Migration of neurons during cortical development is often assumed to rely on purely post-proliferative reelin signaling. However, Notch signaling, long known to regulate neural precursor formation and maintenance, is required for the effects of reelin on neuronal migration. Here, we show that reelin gain-of-function causes a higher expression of Notch target genes in radial glia and accelerates the production of...
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