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Article

Sustained activation of mTOR pathway in embryonic neural stem cells leads to development of tuberous sclerosis complex-associated lesions.

Cell stem cell - 4 Nov 2011

Magri Laura, Cambiaghi Marco, Cominelli Manuela, Alfaro-Cervello Clara, Cursi Marco, Pala Mauro, Bulfone Alessandro, Garcìa-Verdugo Jose Manuel, Leocani Letizia, Minicucci Fabio, Poliani Pietro Luigi, Galli Rossella

Abstract excerpt

Tuberous Sclerosis Complex (TSC) is a multisystem genetic disorder characterized by hamartomatous neurological lesions that exhibit abnormal cell proliferation and differentiation. Hyperactivation of mTOR pathway by mutations in either the Tsc1 or Tsc2 gene underlies TSC pathogenesis, but involvement of specific neural cell populations in the formation of TSC-associated neurological lesions remains unclear. We...

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Identifiers

PMID: 22056141
DOI: 10.1016/j.stem.2011.09.008

Genes

STAT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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