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Article

ApoER2 and VLDLr are required for mediating reelin signalling pathway for normal migration and positioning of mesencephalic dopaminergic neurons.

PloS one - 1 Jan 2013

Sharaf Ahmed, Bock Hans H, Spittau Björn, Bouché Elisabeth, Krieglstein Kerstin

Abstract excerpt

The migration of mesencephalic dopaminergic (mDA) neurons from the subventricular zone to their final positions in the substantia nigra compacta (SNc), ventral tegmental area (VTA), and retrorubral field (RRF) is controlled by signalling from neurotrophic factors, cell adhesion molecules (CAMs) and extracellular matrix molecules (ECM). Reelin and the cytoplasmic adaptor protein Disabled-1 (Dab1) have been shown...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23976984
DOI: 10.1371/journal.pone.0071091
PMCID: PMC3745466

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