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Article

Rheb and mTOR regulate neuronal polarity through Rap1B.

The Journal of biological chemistry - 28 Nov 2008

Li Ying-Hua, Werner Hendrikje, Püschel Andreas W

Abstract excerpt

The development of polarized hippocampal neurons with a single axon and multiple dendrites depends on the activity of phosphoinositide 3-kinase (PI3K) and the GTPase Rap1B. Here we show that PI3K regulates axon specification and elongation through the GTPase Rheb and its target mammalian target of rapamycin (mTOR). Overexpression of Rheb induces the formation of multiple axons, whereas its suppression by RNA...

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Identifiers

PMID: 18842593
DOI: 10.1074/jbc.M802431200
PMCID: PMC2662285

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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