Article
Polymorphic Variants of Cytochrome P450: Relevance to Cancer and Other Diseases.
Advances in pharmacology (San Diego, Calif.) - 1 Jan 2015
Daly Ann K
Abstract excerpt
Associations of cytochrome P450 (CYP) polymorphisms with risk of disease development have been reported widely. For lung cancer, a large number of studies on CYP1A1, CYP2D6, and CYP2A6 polymorphisms have been performed. However, recent studies, including meta-analyses and genome-wide association studies, suggest that only the CYP2A6 association, where genotypes associated with low activity decrease susceptibility...
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