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Genic-intergenic polymorphisms of CYP1A genes and their clinical impact.

Gene - 20 Mar 2023

Kukal Samiksha, Thakran Sarita, Kanojia Neha, Yadav Saroj, Mishra Manish Kumar, Guin Debleena, Singh Pooja, Kukreti Ritushree

Abstract excerpt

The humancytochrome P450 1A (CYP1A) subfamily genes, CYP1A1 and CYP1A2, encoding monooxygenases are critically involved in biotransformation of key endogenous substrates (estradiol, arachidonic acid, cholesterol) and exogenous compounds (smoke constituents, carcinogens, caffeine, therapeutic drugs). This suggests their significant involvement in multiple biological pathways with a primary role of maintaining...

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PMID: 36623673
DOI: 10.1016/j.gene.2023.147171

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