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Article

Molecular genetics and epigenetics of the cytochrome P450 gene family and its relevance for cancer risk and treatment.

Human genetics - 1 Jan 2010

Rodriguez-Antona Cristina, Gomez Alvin, Karlgren Maria, Sim Sarah C, Ingelman-Sundberg Magnus

Abstract excerpt

The cytochromes P450 (CYPs) are very efficient catalysts of foreign compound metabolism and are responsible for the major part of metabolism of clinically important drugs. The enzymes are important in cancer since they (a) activate dietary and environmental components to ultimate carcinogens, (b) activate or inactivate drugs used for cancer treatment, and (c) are potential targets for anticancer therapy. The...

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Identifiers

PMID: 19823875
DOI: 10.1007/s00439-009-0748-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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