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Genetic Polymorphism and Toxicology—With Emphasis on Cytochrome P450

13 Dec 2010

Abstract excerpt

Individual susceptibility to environmental, chemical, and drug toxicity is to some extent determined by polymorphism in drug-metabolizing enzymes, in particular the cytochromes P450 (CYPs). This polymorphism is in particular translated into risk differences concerning drugs metabolized by the highly polymorphic enzymes CYP2C9, CYP2C19, and CYP2D6, whereas CYP enzymes active in procarcinogen activation are...

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PMID: 21149643
DOI: 10.1093/toxsci/kfq374

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