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Article

Cytochrome P450: Polymorphisms and Roles in Cancer, Diabetes and Atherosclerosis

Asian Pacific journal of cancer prevention : APJCP - 24 Aug 2018

Elfaki Imadeldin, Mir Rashid, Almutairi Fahad M, Duhier Faisel M Abu

Abstract excerpt

Cytochromes P450s (CYPs) constitute a superfamily of enzymes that catalyze the metabolism of drugs and other substances. Endogenous substrates of CYPs include eicosanoids, estradiol, arachidonic acids, cholesterol, vitamin D and neurotransmitters. Exogenous substrates of CYPs include the polycyclic aromatic hydrocarbons and about 80% of currently used drugs. Some isoforms can activate procarcinogens to ultimate...

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Identifiers

PMID: 30139042
DOI: 10.22034/APJCP.2018.19.8.2057
PMCID: PMC6171375

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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