Article
Two microtubule-plus-end binding proteins LIS1-1 and LIS1-2, homologues of human LIS1 in Neurospora crassa.
Fungal genetics and biology : FG & B - 1 Sept 2015
Callejas-Negrete Olga A, Plamann Michael, Schnittker Robert, Bartnicki-García Salomon, Roberson Robert W, Pimienta Genaro, Mouriño-Pérez Rosa R
Abstract excerpt
LIS1 is a microtubule (Mt) plus-end binding protein that interacts with the dynein/dynactin complex. In humans, LIS1 is required for proper nuclear and organelle migration during cell growth. Although gene duplication is absent from Neurospora crassa, we found two paralogues of human LIS1. We named them LIS1-1 and LIS1-2 and studied their dynamics and function by fluorescent tagging. At the protein level, LIS1-1...
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