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Article

lis-1 is required for dynein-dependent cell division processes in C. elegans embryos.

Journal of cell science - 1 Sept 2004

Cockell Moira M, Baumer Karine, Gönczy Pierre

Abstract excerpt

We investigated the role of the evolutionarily conserved protein Lis1 in cell division processes of Caenorhabditis elegans embryos. We identified apparent null alleles of lis-1, which result in defects identical to those observed after inactivation of the dynein heavy chain dhc-1, including defects in centrosome separation and spindle assembly. We raised antibodies against LIS-1 and generated transgenic animals...

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Source

Identifiers

PMID: 15331665
DOI: 10.1242/jcs.01344

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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lis-1 is required for dynein-dependent cell division processes in C. elegans embryos.PMID 15331665Read ↗

Cytoplasmic dynein light intermediate chain is required for discrete aspects of mitosis in Caenorhabditis elegans.Semantic proximity Read ↗

Role of dynein, dynactin, and CLIP-170 interactions in LIS1 kinetochore function.Semantic proximity Read ↗

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Lis1, the Drosophila homolog of a human lissencephaly disease gene, is required for germline cell division and oocyte differentiation.Semantic proximity Read ↗

Employing the one-cell C. elegans embryo to study cell division processes.Semantic proximity Read ↗

Muscle length and myonuclear position are independently regulated by distinct Dynein pathwaysSemantic proximity Read ↗

Distinct dose-dependent cortical neuronal migration and neurite extension defects in Lis1 and Ndel1 mutant mice.Semantic proximity Read ↗

<i>C. elegans</i> SAS-1 ensures centriole integrity and ciliary function, and operates with SSNA-1Semantic proximity Read ↗

[Molecular mechanism of lissencephaly--how LIS1 and NDEL1 regulate cytoplasmic dynein?].Semantic proximity Read ↗

The C. elegans zyg-1 gene encodes a regulator of centrosome duplication with distinct maternal and paternal roles in the embryo.Semantic proximity Read ↗

The conserved protein SZY-20 opposes the Plk4-related kinase ZYG-1 to limit centrosome size.Semantic proximity Read ↗

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