Article
Rasd2 Modulates Prefronto-Striatal Phenotypes in Humans and 'Schizophrenia-Like Behaviors' in Mice.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Feb 2016
Vitucci Daniela, Di Giorgio Annabella, Napolitano Francesco, Pelosi Barbara, Blasi Giuseppe, Errico Francesco, Attrotto Maria Teresa, Gelao Barbara, Fazio Leonardo, Taurisano Paolo, Di Maio Anna, Marsili Valentina, Pasqualetti Massimo, Bertolino Alessandro, Usiello Alessandro
Abstract excerpt
Rasd2 is a thyroid hormone target gene, which encodes for a GTP-binding protein enriched in the striatum where, among other functions, it modulates dopaminergic neurotransmission. Here we report that human RASD2 mRNA is abundant in putamen, but it also occurs in the cerebral cortex, with a distinctive expression pattern that differs from that present in rodents. Consistent with its localization, we found that a...
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