Article
DRD2 Schizophrenia-Risk Allele Is Associated With Impaired Striatal Functioning in Unaffected Siblings of Schizophrenia Patients.
Schizophrenia bulletin - 1 May 2016
Vink Matthijs, de Leeuw Max, Luykx Jurjen J, van Eijk Kristel R, van den Munkhof Hanna E, van Buuren Mariët, Kahn René S
Abstract excerpt
A recent Genome-Wide Association Study showed that the rs2514218 single nucleotide polymorphism (SNP) in close proximity to dopamine receptor D2 is strongly associated with schizophrenia. Further, an in silico experiment showed that rs2514218 has a cis expression quantitative trait locus effect in the basal ganglia. To date, however, the functional consequence of this SNP is unknown. Here, we used functional...
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