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Article

The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry.

Nature neuroscience - 1 Aug 2013

Hess Martin E, Hess Simon, Meyer Kate D, Verhagen Linda A W, Koch Linda, Brönneke Hella S, Dietrich Marcelo O, Jordan Sabine D, Saletore Yogesh, Elemento Olivier, Belgardt Bengt F, Franz Thomas, Horvath Tamas L, Rüther Ulrich, Jaffrey Samie R, Kloppenburg Peter, Brüning Jens C

Abstract excerpt

Dopaminergic (DA) signaling governs the control of complex behaviors, and its deregulation has been implicated in a wide range of diseases. Here we demonstrate that inactivation of the Fto gene, encoding a nucleic acid demethylase, impairs dopamine receptor type 2 (D2R) and type 3 (D3R) (collectively, 'D2-like receptor')-dependent control of neuronal activity and behavioral responses. Conventional and DA...

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Source

Identifiers

PMID: 23817550
DOI: 10.1038/nn.3449

Genes

FTO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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