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Article

Increased caudate dopamine D2 receptor availability as a genetic marker for schizophrenia.

Archives of general psychiatry - 1 Apr 2005

Hirvonen Jussi, van Erp Theo G M, Huttunen Jukka, Aalto Sargo, Någren Kjell, Huttunen Matti, Lönnqvist Jouko, Kaprio Jaakko, Hietala Jarmo, Cannon Tyrone D

Abstract excerpt

CONTEXT: Schizophrenia has a heritability of about 80%, but the detailed molecular genetic basis of the disorder has remained elusive. Relative hyperfunction of the subcortical dopamine system has been previously suggested to be one of the key pathophysiologic mechanisms in schizophrenic psychosis. OBJECTIVE: To examine the contributions of genetic vulnerability for schizophrenia to the dopamine system in the...

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PMID: 15809404
DOI: 10.1001/archpsyc.62.4.371

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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