Article
Contrasting changes in DRD1 and DRD2 splice variant expression in schizophrenia and affective disorders, and associations with SNPs in postmortem brain.
Molecular psychiatry - 1 Dec 2014
Kaalund S S, Newburn E N, Ye T, Tao R, Li C, Deep-Soboslay A, Herman M M, Hyde T M, Weinberger D R, Lipska B K, Kleinman J E
Abstract excerpt
Dopamine 2 receptor (DRD2) is of major interest to the pathophysiology of schizophrenia (SCZ) both as a target for antipsychotic drug action as well as a SCZ-associated risk gene. The dopamine 1 receptor (DRD1) is thought to mediate some of the cognitive deficits in SCZ, including impairment of working memory that relies on normal dorsolateral prefrontal cortex (DLPFC) function. To better understand the...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Bipolar Disorder
- Brain
- Child
- Child, Preschool
- Cohort Studies
- Depressive Disorder, Major
- Female