Article
Multiple autoimmune-associated variants confer decreased IL-2R signaling in CD4+ CD25(hi) T cells of type 1 diabetic and multiple sclerosis patients.
PloS one - 1 Jan 2013
Cerosaletti Karen, Schneider Anya, Schwedhelm Katharine, Frank Ian, Tatum Megan, Wei Shan, Whalen Elizabeth, Greenbaum Carla, Kita Mariko, Buckner Jane, Long S Alice
Abstract excerpt
IL-2 receptor (IL-2R) signaling is essential for optimal stability and function of CD4(+)CD25(hi)FOXP3(+) regulatory T cells (Treg); a cell type that plays an integral role in maintaining tolerance. Thus, we hypothesized that decreased response to IL-2 may be a common phenotype of subjects who have autoimmune diseases associated with variants in the IL2RA locus, including T1D and MS, particularly in cells...
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