Article
A Crohn's Disease-associated IL2RA Enhancer Variant Determines the Balance of T Cell Immunity by Regulating Responsiveness to IL-2 Signalling.
Journal of Crohn's & colitis - 18 Dec 2021
Goldberg Rimma, Clough Jennie N, Roberts Luke B, Sanchez Jenifer, Kordasti Shahram, Petrov Nedyalko, Hertweck Arnulf, Lorenc Anna, Jackson Ian, Tasker Scott, Appios Anna, Omer Omer, Parkes Miles, Prescott Natalie, Jenner Richard G, Irving Peter M, Lord Graham M
Abstract excerpt
BACKGROUND AND AIMS: Differential responsiveness to interleukin [IL]-2 between effector CD4+ T cells [Teff] and regulatory T cells [Treg] is a fundamental mechanism of immunoregulation. The single nucleotide polymorphism [SNP] rs61839660, located within IL2RA [CD25], has been associated with the development of Crohn's disease [CD]. We sought to identify the T cell immune phenotype of IBD patients who carry this...
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