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Article

The MPH1 gene of Saccharomyces cerevisiae functions in Okazaki fragment processing.

The Journal of biological chemistry - 17 Apr 2009

Kang Young-Hoon, Kang Min-Jung, Kim Jeong-Hoon, Lee Chul-Hwan, Cho Il-Taeg, Hurwitz Jerard, Seo Yeon-Soo

Abstract excerpt

Saccharomyces cerevisiae MPH1 was first identified as a gene encoding a 3' to 5' DNA helicase, which when deleted leads to a mutator phenotype. In this study, we isolated MPH1 as a multicopy suppressor of the dna2K1080E helicase-negative lethal mutant. Purified Mph1 stimulated the endonuclease activities of both Fen1 and Dna2, which act faithfully in the processing of Okazaki fragments. This stimulation required...

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Identifiers

PMID: 19181670
DOI: 10.1074/jbc.M808894200
PMCID: PMC2667725

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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