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Article

Point mutation of cytochrome P450 2A6 (a polymorphic variant CYP2A6.25) confers new substrate specificity towards flavonoids.

Biopharmaceutics & drug disposition - 1 Nov 2015

Uno Tomohide, Ogura Chika, Izumi Chiho, Nakamura Masahiko, Yanase Takeshi, Yamazaki Hiroshi, Ashida Hitoshi, Kanamaru Kengo, Yamagata Hiroshi, Imaishi Hiromasa

Abstract excerpt

CYP2A6 is a major hepatic member of the cytochrome P450 family in humans. Much variation in CYP2A6 levels and activity can be attributed to genetic polymorphisms of this gene. CYP2A6*25 comprises an amino acid substitution, F118L. To clarify the effect of the leucine substitution at position 118 in CYP2A6.25, this variant, wild type CYP2A6 and three additional variants consisting of artificial mutations at the...

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Identifiers

PMID: 26222491
DOI: 10.1002/bdd.1966

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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