Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CDK8-Cyclin C Mediates Nutritional Regulation of Developmental Transitions through the Ecdysone Receptor in Drosophila.

PLoS biology - 1 Jul 2015

Xie Xiao-Jun, Hsu Fu-Ning, Gao Xinsheng, Xu Wu, Ni Jian-Quan, Xing Yue, Huang Liying, Hsiao Hao-Ching, Zheng Haiyan, Wang Chenguang, Zheng Yani, Xiaoli Alus M, Yang Fajun, Bondos Sarah E, Ji Jun-Yuan

Abstract excerpt

The steroid hormone ecdysone and its receptor (EcR) play critical roles in orchestrating developmental transitions in arthropods. However, the mechanism by which EcR integrates nutritional and developmental cues to correctly activate transcription remains poorly understood. Here, we show that EcR-dependent transcription, and thus, developmental timing in Drosophila, is regulated by CDK8 and its regulatory partner...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Genetically Modified
Share to DNA-Binding Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drosophila

Share to Drosophila Proteins

Share to Food Deprivation

Share to Gene Expression Regulation

Share to Receptors, Steroid

Source

Open in PubMed Open full text

Identifiers

PMID: 26222308
DOI: 10.1371/journal.pbio.1002207
PMCID: PMC4519132

Genes

CDK8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CDK8-Cyclin C Mediates Nutritional Regulation of Developmental Transitions through the Ecdysone Receptor in Drosophila.PMID 26222308Read ↗

A Drosophila Genome-Wide Screen Identifies Regulators of Steroid Hormone Production and Developmental Timing.Semantic proximity Read ↗

Distinct effects of CDK8 module subunits on cellular growth and proliferation in <i>Drosophila</i>Semantic proximity Read ↗

Opportunistic binding of EcR to open chromatin drives tissue-specific developmental responsesSemantic proximity Read ↗

Genetic control of specificity to steroid-triggered responses in Drosophila.Semantic proximity Read ↗

The Drosophila ecdysone receptor (EcR) gene is required maternally for normal oogenesis.Semantic proximity Read ↗

Isoform-specific regulation of a steroid hormone nuclear receptor by an E3 ubiquitin ligase in Drosophila melanogaster.Semantic proximity Read ↗

Ecdysone signaling in adult Drosophila melanogaster.Semantic proximity Read ↗

Drosophila estrogen-related receptor directs a transcriptional switch that supports adult glycolysis and lipogenesis.Semantic proximity Read ↗

E2F/Dp inactivation in fat body cells triggers systemic metabolic changes.Semantic proximity Read ↗

An EcR probe reveals mechanisms of the ecdysone-mediated switch from repression-to-activation on target genes in the larval wing discSemantic proximity Read ↗

The DHR78 nuclear receptor is required for ecdysteroid signaling during the onset of Drosophila metamorphosis.Semantic proximity Read ↗

A novel nuclear receptor/coregulator complex controls C. elegans lipid metabolism, larval development, and aging.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.