The DHR78 nuclear receptor is required for ecdysteroid signaling during the onset of Drosophila metamorphosis.

doi:10.1016/s0092-8674(00)81184-8

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Article

The DHR78 nuclear receptor is required for ecdysteroid signaling during the onset of Drosophila metamorphosis.

Cell - 15 May 1998

Fisk G J, Thummel C S

Abstract excerpt

Pulses of ecdysteroids direct Drosophila through its life cycle by activating stage- and tissue-specific genetic regulatory hierarchies. Here we show that an orphan nuclear receptor, DHR78, functions at the top of the ecdysteroid regulatory hierarchies. Null mutations in DHR78 lead to lethality during the third larval instar with defects in ecdysteroid-triggered developmental responses. Consistent with these...

Topics

Animals
Chromosomes
DNA-Binding Proteins
Drosophila
Drosophila Proteins
Ecdysteroids
Ecdysterone
Gene Expression Regulation, Developmental
Genes, Insect
Genes, Lethal
Larva
Metamorphosis, Biological

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Organ Specificity

Phenotype

RNA, Messenger

Receptors, Cytoplasmic and Nuclear

Restriction Mapping

Source

Open in PubMed

Identifiers

PMID: 9604930
DOI: 10.1016/s0092-8674(00)81184-8

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