Article

An EcR probe reveals mechanisms of the ecdysone-mediated switch from repression-to-activation on target genes in the larval wing disc

2022-04-08

Abstract excerpt

Fluctuating levels of steroid hormones provide both systemic and local cues to synchronize metazoan development and control germline and homeostatic processes. The main steroid hormone in Drosophila is ecdysone (Ec), which upon binding of its active form (20E) converts its receptor, EcR, from a transcriptional repressor to activator. Multiple co-repressors and co-activators are proposed to act with EcR in differe...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2cb8fd91-7110-5975-950e-fe03afcb0ca6
DOI: 10.1101/2022.04.07.487542

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

An EcR probe reveals mechanisms of the ecdysone-mediated switch from repression-to-activation on target genes in the larval wing discDOI 10.1101/2022.04.07.487542Read

Opportunistic binding of EcR to open chromatin drives tissue-specific developmental responsesSemantic proximity Read

SMRTER, a Drosophila nuclear receptor coregulator, reveals that EcR-mediated repression is critical for development.Semantic proximity Read

Control of target gene specificity during metamorphosis by the steroid response gene E93.Semantic proximity Read

Ecdysone signaling in adult Drosophila melanogaster.Semantic proximity Read

<i>Ecdysone Receptor</i> autonomously controls germ cell differentiation in the <i>Drosophila</i> ovarySemantic proximity Read

CDK8-Cyclin C Mediates Nutritional Regulation of Developmental Transitions through the Ecdysone Receptor in Drosophila.Semantic proximity Read

Isoform-specific regulation of a steroid hormone nuclear receptor by an E3 ubiquitin ligase in Drosophila melanogaster.Semantic proximity Read

The DHR78 nuclear receptor is required for ecdysteroid signaling during the onset of Drosophila metamorphosis.Semantic proximity Read

The Drosophila ecdysone receptor (EcR) gene is required maternally for normal oogenesis.Semantic proximity Read

Genetic control of specificity to steroid-triggered responses in Drosophila.Semantic proximity Read

Molecular Chaperones Activate the Drosophila Ecdysone Receptor, an RXR HeterodimerSemantic proximity Read

Nuclear receptor DHR4 controls the timing of steroid hormone pulses during Drosophila development.Semantic proximity Read