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Article

A novel nuclear receptor/coregulator complex controls C. elegans lipid metabolism, larval development, and aging.

Genes & development - 1 Sept 2004

Ludewig Andreas H, Kober-Eisermann Corinna, Weitzel Cindy, Bethke Axel, Neubert Kerstin, Gerisch Birgit, Hutter Harald, Antebi Adam

Abstract excerpt

Environmental cues transduced by an endocrine network converge on Caenorhabditis elegans nuclear receptor DAF-12 to mediate arrest at dauer diapause or continuous larval development. In adults, DAF-12 selects long-lived or short-lived modes. How these organismal choices are molecularly specified is unknown. Here we show that coregulator DIN-1 and DAF-12 physically and genetically interact to instruct organismal...

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Identifiers

PMID: 15314028
DOI: 10.1101/gad.312604
PMCID: PMC515290

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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