Article
Isoform-specific regulation of a steroid hormone nuclear receptor by an E3 ubiquitin ligase in Drosophila melanogaster.
Genetics - 1 Nov 2011
Gradilla Ana-Citlali, Mansilla Alicia, Ferrús Alberto
Abstract excerpt
The steroid hormone 20-hydroxyecdysone (20E) regulates gene transcription through the heterodimeric nuclear receptor composed of ecdysone receptor (EcR) and Ultraspiracle (USP). The EcR gene encodes three protein isoforms--A, B1, and B2--with variant N-terminal domains that mediate tissue and developmental stage-specific responses to 20E. Ariadne-1a is a conserved member of the RING finger family of ubiquitin...
Topics
- Active Transport, Cell Nucleus
- Animals
- Cell Line
- Cell Nucleus
- DNA-Binding Proteins
- Drosophila Proteins
- Drosophila melanogaster
- Ecdysone
- Female
- Gene Expression Regulation
- Male
- Metamorphosis, Biological
- Phenotype
- Protein Isoforms