Article
E2F/Dp inactivation in fat body cells triggers systemic metabolic changes.
eLife - 12 Jul 2021
Zappia Maria Paula, Guarner Ana, Kellie-Smith Nadia, Rogers Alice, Morris Robert, Nicolay Brandon, Boukhali Myriam, Haas Wilhelm, Dyson Nicholas J, Frolov Maxim V
Abstract excerpt
The E2F transcription factors play a critical role in controlling cell fate. In Drosophila, the inactivation of E2F in either muscle or fat body results in lethality, suggesting an essential function for E2F in these tissues. However, the cellular and organismal consequences of inactivating E2F in these tissues are not fully understood. Here, we show that the E2F loss exerts both tissue-intrinsic and systemic...
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