Article
Analysis of KRAS and NRAS Gene Mutations in Arab Asian Children With Acute Leukemia: High Frequency of RAS Mutations in Acute Lymphoblastic Leukemia.
Pediatric blood & cancer - 1 Dec 2015
Al-Kzayer Lika'a Fasih Y, Sakashita Kazuo, Al-Jadiry Mazin Faisal, Al-Hadad Salma Abbas, Ghali Hasanein Habeeb, Uyen Le T N, Liu Tingting, Matsuda Kazuyuki, Abdulkadhim Jaafar M H, Al-Shujairi Tariq Abadi, Matti Zead Ismael I K, Sughayer Maher A, Rihani Rawad, Madanat Faris F, Inoshita Toshi, Kamata Minoru, Koike Kenichi
Abstract excerpt
BACKGROUND: KRAS and NRAS gene mutations are frequently observed in childhood leukemia. The objective of this study was to determine the frequency of RAS mutations and the association between RAS mutations and other genetic aberrations in Arab Asian children with acute lymphoblastic leukemia (ALL) or acute myeloid leukemia (AML). METHODS: Diagnostic samples of 485 patients (<18 years) with acute leukemia from...
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