Article
NRAS mutations in de novo acute leukemia: prevalence and clinical significance.
Indian journal of biochemistry & biophysics - 1 Jun 2014
Dunna Nageswara Rao, Vuree Sugunakar, Anuradha Cingeetham, Sailaja Kagita, Surekha Damineni, Digumarti Raghunadha Rao, Rao V R, Yadav Satish Kumar, Reddy Rajasekhar, Vishnupriya Satti
Abstract excerpt
The activating mutations of the Ras gene or other abnormalities in Ras signaling pathway lead to uncontrolled growth factor-independent proliferation of hematopoietic progenitors. Oncogenic mutations in NRAS gene have been observed with variable prevalence in hematopoietic malignancies. In the present study, NRAS mutations were detected using bidirectional sequencing in 264 acute leukemia cases--129 acute...
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