Article
RAS mutations are frequent in FAB type M4 and M5 of acute myeloid leukemia, and related to late relapse: a study of the Japanese Childhood AML Cooperative Study Group.
International journal of hematology - 1 May 2012
Sano Hirozumi, Shimada Akira, Taki Tomohiko, Murata Chisato, Park Myoung-Ja, Sotomatsu Manabu, Tabuchi Ken, Tawa Akio, Kobayashi Ryoji, Horibe Keizo, Tsuchida Masahiro, Hanada Ryoji, Tsukimoto Ichiro, Hayashi Yasuhide
Abstract excerpt
Mutations in RAS are frequent in acute myeloid leukemia (AML), and are thought to contribute to leukemogenesis in a subset of patients; however, their prognostic significance has not been firmly established. One hundred and fifty-seven pediatric patients with AML were analyzed for NRAS and KRAS mutations around hot spots at codons 12, 13, and 61. Twenty-nine patients (18.5%) had an activating mutation of RAS. We...
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