K‐<i>ras</i> mutations and N‐<i>ras</i> mutations in childhood acute leukemias with or without mixed‐lineage leukemia gene rearrangements

Abstract excerpt

BACKGROUND: It is believed that Ras mutations drive the proliferation of leukemic cells. The objective of this study was to investigate the association of Ras mutations with childhood acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) with special reference to the presence or absence of mixed-lineage leukemia gene (MLL) rearrangements. METHODS: Bone marrow samples from 313 children with...

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