Article
Frequent coexistence of RAS mutations in RUNX1-mutated acute myeloid leukemia in Arab Asian children.
Pediatric blood & cancer - 1 Nov 2014
Al-Kzayer Lika'a Fasih Y, Sakashita Kazuo, Al-Jadiry Mazin Faisal, Al-Hadad Salma Abbas, Uyen Le T N, Liu Tingting, Matsuda Kazuyuki, Abdulkadhim Jaafar M H, Al-Shujairi Tariq Abadi, Matti Zead Ismael I K, Hasan Janan Ghalib, Al-Abdullah Hussam M Salih, Inoshita Toshi, Kamata Minoru, Sughayer Maher A, Madanat Faris F, Koike Kenichi
Abstract excerpt
BACKGROUND: RUNX1 mutation plays an important role in adult leukemic transformation. However, its contribution to the development of childhood leukemia remains unclear. In the present study, we analyzed point mutations of RUNX1 gene in children and adolescents with acute myeloid leukemia (AML) from Iraq and Jordan. PROCEDURE: Bone marrow and/or peripheral blood samples were collected from 178 patients of Arab...
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