Article
Regulation of the protein kinase PKR by the vaccinia virus pseudosubstrate inhibitor K3L is dependent on residues conserved between the K3L protein and the PKR substrate eIF2alpha.
Molecular and cellular biology - 1 Jul 1997
Kawagishi-Kobayashi M, Silverman J B, Ung T L, Dever T E
Abstract excerpt
The mammalian double-stranded RNA-activated protein kinase PKR is a component of the cellular antiviral defense mechanism and phosphorylates Ser-51 on the alpha subunit of the translation factor eIF2 to inhibit protein synthesis. To identify the molecular determinants that specify substrate recog...
Topics
- Alleles
- Amino Acid Sequence
- Consensus Sequence
- DNA Mutational Analysis
- DNA-Binding Proteins
- Enzyme Inhibitors
- Eukaryotic Initiation Factor-2
- Fungal Proteins
- Molecular Sequence Data
- Phosphorylation
- Protein Binding
- Protein Kinases
- Protein Serine-Threonine Kinases