Article
Regulation of the protein kinase PKR by the vaccinia virus pseudosubstrate inhibitor K3L is dependent on residues conserved between the K3L protein and the PKR substrate eIF2alpha.
Molecular and cellular biology - 1 Jul 1997
Kawagishi-Kobayashi M, Silverman J B, Ung T L, Dever T E
Abstract excerpt
The mammalian double-stranded RNA-activated protein kinase PKR is a component of the cellular antiviral defense mechanism and phosphorylates Ser-51 on the alpha subunit of the translation factor eIF2 to inhibit protein synthesis. To identify the molecular determinants that specify substrate recognition by PKR, we performed a mutational analysis on the vaccinia virus K3L protein, a pseudosubstrate inhibitor of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.