Article
The direct binding of the catalytic subunit of protein phosphatase 1 to the PKR protein kinase is necessary but not sufficient for inactivation and disruption of enzyme dimer formation.
The Journal of biological chemistry - 27 Sept 2002
Tan Seng-Lai, Tareen Semih U, Melville Mark W, Blakely Collin M, Katze Michael G
Abstract excerpt
The PKR protein kinase is among the best-studied effectors of the host interferon (IFN)-induced antiviral and antiproliferative response system. In response to stress signals, including virus infection, the normally latent PKR becomes activated through autophosphorylation and dimerization and phosphorylates the eIF2alpha translation initiation factor subunit, leading to an inhibition of mRNA translation...
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